The nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate/D-NO), increases survival by attenuating hyperoxia-compromised innate immunity in bacterial clearance in a mouse model of ventilator-associated pneumonia
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منابع مشابه
The Nitric Oxide Donor, O-Vinyl 1-(Pyrrolidin-1-yl)diazen-1- ium-1,2-diolate (V-PYRRO/NO), Protects against Cadmium-Induced Hepatotoxicity in Mice
The nitric oxide (NO) donor, O-vinyl 1-(pyrrolidin-1-yl)diazen1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO within the liver and is effective in protecting against hepatotoxicity of endotoxin and acetaminophen. This study examined the effects of V-PYRRO/NO on cadmium (Cd) hepatotoxicity in mice. Mice were given multiple injections of V-PYRRO/NO (10 mg/kg, s.c. at ...
متن کاملThe nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice.
The nitric oxide (NO) donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO within the liver and is effective in protecting against hepatotoxicity of endotoxin and acetaminophen. This study examined the effects of V-PYRRO/NO on cadmium (Cd) hepatotoxicity in mice. Mice were given multiple injections of V-PYRRO/NO (10 mg/kg, s.c. a...
متن کاملNitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma.
Susceptibility of dendritic cells (DCs) to tumor-induced apoptosis reduces their efficacy in cancer therapy. Here we show that delivery within exponentially growing B16 melanomas of DCs treated ex vivo with nitric oxide (NO), released by the NO donor (z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NO), significantly reduced tumor growth, with cure of 37% of animal...
متن کامل(Z)-N-(2-Chlorobenzylidene)aniline N-oxide
In the title compound, C(13)H(10)ClNO, the central C-N bond has considerable double-bond character and the N-O bond indicates a formal negative charge on the O atom. The mol-ecule is stabilized by an intra-molecular C-H⋯O hydrogen bond. The geometry about the C=N bond is Z [C-C-N-O torsion angle = -4.2 (3)°] and the phenyl and benzene rings are trans-oriented around the C=N bond. The phenyl and...
متن کاملEfficient Reverse Converter for Three Modules Set {2^n-1,2^(n+1)-1,2^n} in Multi-Part RNS
Residue Number System is a numerical system which arithmetic operations are performed parallelly. One of the main factors that affects the system’s performance is the complexity of reverse converter. It should be noted that the complexity of this part should not affect the earned speed of parallelly performed arithmetic unit. Therefore in this paper a high speed converter for moduli set {2n-1, ...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2020
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2020.113817